Objective: To review data on pharmacokinetic factors that influence the absorption and tissue distribution for individual antibiotic agents to better inform clinicians on rational dosing considerations of oral antibiotics for the treatment of acne vulgaris. The focus is placed on the most commonly prescribed oral antibiotics for acne vulgaris, the tetracyclines. Dose-response is also reviewed. Design and methods: This review describes factors affecting the absorption, distribution, and target tissue penetration of the most frequently prescribed oral antibiotics for the treatment of acne vulgaris, the tetracyclines. Articles cited were identified by a search of PubMed covering the period from January 1, , to November 15,
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Acne is caused by the effects of hormones on this unit. Specifically, the follicle becomes obstructed and an overgrowth of normal skin bacteria, Propionibacterium acnes , causes the destruction of the lining of the follicle. This process allows the follicular material to enter the dermis, causing an inflammatory response.